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In most human GST isozymes the amino acid acting as the proton acceptor is a tyrosine, the phenol function of which is itself deprotonated by a neighboring strongly basic amino acid residue

Some patients may experience temporary water retention, mild acne, or irritation at the injection site

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Meanwhile, the endogenous neurotrophic factor system, especially its members with high affinity and specificity for midbrain dopaminergic neurons, constitutes an important defense mechanism against neurodegeneration