Abbreviations PsO: Psoriasis IMQ: Imiquimod PUVA: Psoralen + Ultraviolet A HaCaT: Human adult low calcium high temperature (immortalized keratinocyte cell line) PASI: Psoriasis area and severity index NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells JAK: Janus kinase STAT: Signal transducer and activator of transcription STAT3: Signal transducer and activator of transcription 3 IL: Interleukin TNF-: Tumor necrosis factor-alpha TNF: Tumor necrosis factor IFN-: Interferon-gamma EGCG: Epigallocatechin gallate ROS: Reactive oxygen species Nrf2: Nuclear factor erythroid 2related factor 2 UV: Ultraviolet BALB/c: Mouse strain EE: Entrapment efficiency NLC: Nanostructured lipid carrier SLN: Solid lipid nanoparticles PVA: Polyvinyl alcohol MS: Multiple sclerosis AA: Arachidonic acid SK: Skin MA: Methacrylic acid SA: Stearic acid References Morrone A, DellAnna ML, Cristaudo A, Wubayehu T, Godefay H, Barnabas GA, et al
It is genetically encoded by two possible codons (nucleotide triplets of mRNA) UGU and UGC
Similarly, silencing GSTO1 or inhibition of its catalytic activity increased cellular levels of protein glutathionylation 14
Chronic Oxidative Stress (Depletes Glutathione Faster Than Its Made) Anything that increases free radical production depletes glutathione: Chronic inflammation (autoimmune diseases, obesity, metabolic syndrome) Environmental toxins (air pollution, pesticides, heavy metals) Alcohol consumption (glutathione is rapidly depleted in liver detoxification) Poor diet (high in processed foods, seed oils, sugar) Intense exercise (without adequate recovery) When oxidative stress exceeds your bodys capacity to recycle GSSG back to GSH, levels drop [4]
10.2106/00004623-200604002-00005 133 KawaguchiY.OsadaR.KanamoriM.IshiharaH.OhmoriK.MatsuiH.et al (1999)
