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The development of AP not only impairs the exocrine digestive function of the pancreas but also disrupts its endocrine function, leading to dysregulated insulin secretion ( Systemic inflammatory responses in AP interfere with insulin action through multiple mechanisms, leading to exacerbation of IR For instance, elevated levels of IL-6 in the plasma of patients with AP are positively correlated with IR ( Moreover, adipokines play a significant role in linking obesity to pancreatitis severity

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Hsieh M.J., Liu H.T., Wang C.N., Huang H.Y., Lin Y., Ko Y.S., Wang J.S., Chang V.H., Pang J.S

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Cell-type-specific insights into iron regulatory processes

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