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When macrophages internalize oxLDL, they form lipid-laden foam cells within the intima, a distinctive hallmark of early-stage atherosclerotic lesions

The rapid accumulation of multiple isotopologues in metabolites of upper glycolysis and the pentose phosphate pathway (PPP) revealed that GAPDH inhibition by hydrogen peroxide induces rapid diversion of glycolytic flux into the PPP, and further, multiple rounds of cycling of carbons through the oxidative arm to amplify NADPH production and combat ROS (Fig

Hereditary spherocytosis HS is an inherited disorder characterized by the presence of spherical-shaped RBCs on peripheral blood smears and is most commonly associated with autosomal dominant inheritance [23]

The flow rate was 300 nL/min and linear gradient was 90 min (from 5 to 85% B over 67 min

Halassy S., Au K., Chobanian N