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Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma

The methodology was as follows: Peer-reviewed clinical literature indexed in PubMed and PubMed Central was searched with terms including: microneedling , micro-infusion , percutaneous collagen induction therapy , transdermal drug delivery , AquaGold , plus each named active ingredient (GHK-Cu, Argireline, niacinamide, Centella asiatica, hyaluronic acid molecular weight, recombinant epidermal growth factor)

Chen Q, Wu KH, Wang P et al (2013) Overexpression of MsALMT1, from the aluminum-sensitive medicago sativa, enhances malate exudation and aluminum resistance in tobacco

Biochim Biophys Acta 1853:31533164

This invention claims the use of reduced glutathione, with the preferred embodiment the liposomal encapsulation described, for use in disease situations that have occurred along with or secondary to inefficient function of the methionine methylation pathway to enable the restoration of the methionine cycle in disease states such as, but not limited to, autism