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However, the manifestations of the disease, such as skin pigmentation and soft tissue growth, were noted much earlier, with descriptions dating back to ancient times in some medical literature

Researchers at Baylor School of Medicine used a combination of animal and human studies to explore the role of glutathione in weight management and insulin resistance in older individuals

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Furthermore, unpublished studies often lacked sufficient methodological detail for quality appraisal, outcome data, and long-term follow-up, and the absence of peer review made it difficult to appraise internal validity in a standardised way