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Scientists can also make synthetic peptides in the lab

lactis, Lactobacillus helveticus , Streptococcus gallolyticus subsp

In vitro , low-dose berberine significantly increased PC12 cell viability, whereas high-dose berberine did the opposite (Zhang et al., 2017)

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In fact, NRF2 activation as a clinical target is well established for the treatment of MS since the potent NRF2-activator dimethyl fumarate (DMF) was approved by FDA as first disease-modifying agent in 2013 (Fox et al., 2012