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Genetic context may support informed metabolic conversations but does not replace bloodwork or clinical evaluation

This idea dates back to seminal work from Eagle, who showed that supplementation with extracellular GSH supports cell growth in cystine-free conditions 22

Overall, the development of antisense oligonucleotide and siRNA as DNA demethylating agents is challenging because of their chemical instability, delivery and off-target effects

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Mechanical cues influence YAP and TAZ activity, though these effects have been shown to be at least partially independent of the Hippo pathway (225)