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Quercetin significantly reduces inflammatory factors (TNF-, IL-1) and oxidative stress markers (MDA) while upregulating antioxidant enzymes (SOD, GSH) in DN models by inhibiting PI3K/PKB, AMPK-P38 MAPK, and TGF-1/Smad pathways (Yu et al., 2023)

CL40 inhibits gp42 binding by sterically displacing it from the gH/gL complex

Similarly, Regina Biasibetti et al

Furthermore, the addition of sulfur elevated the content of sulfur-containing compounds, such as GSH, in the root system, and Cd chelated with these sulfur-containing compounds and transported into the root vesicles thereby reducing the transport of Cd from the root system to the A.G