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The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohns disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Gut microbiome interactions with riboflavin: Certain gut microbes can produce riboflavin, part of which is then absorbed into the body

Moreover, while two studies reported significant findings, the inconsistency in statistical significance across all studies highlights the need for large-scale, multicenter, well-powered RCTs to confirm these results [100,101,102]

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