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In such conditions, the APX-MDHAR system could work largely as a closed cycle, with minimal or minor input from glutathione (Fig

Therefore, diazotrophs have a system that strongly inhibits nitrogen fixation in the presence of extracellular inorganic/organic nitrogen-containing compounds, such as ammonium, glutamine, and asparagine, to avoid energy loss 14

However, this normalized state is not achieved in individuals with weak HLA-II haplotypes against EBV, presenting an impaired CD4 T-cell function and, therefore, a deficient CD8 T-cell cytotoxic response