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Neurology 44, 14111417

10.1007/s43188-023-00181-5 35 EserA.HizliD.HaltasH.NamusluM.KosusA.KosusN.et al (2015)

379,380 A phase I clinical trial in which pazopanib and vorinostat were combined to treat patients with p53-mutant tumors suggested that HDAC inhibitors can abolish the proangiogenic function of mutant p53

Furthermore, long-term studies with extended observation periods, doseresponse profiling, and pharmacokinetic evaluation will be necessary to establish optimal dosing regimens and assess clinical safety