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While the precise role of ROS in the pathophysiology of AD has yet to be fully understood, numerous studies have shown that dietary factors which behave as antioxidants, modulate oxidative stress and gene expression of antioxidant enzymes

Even assuming proper stratification has been achieved, any slight deviation in flow rate, liquid level, or valve control during the introduction of the regenerant can lead to acid bleeding into the anionic resin layer or alkali bleeding into the cationic resin layerat which point, the entire regeneration attempt is effectively a failure