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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

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Through conjugation with the DOTA chelator and subsequent radiolabeling with the positron-emitting radionuclide copper-64 ( 64 Cu), daratumumab has been successfully developed as a molecular probe targeting CD38-expressing MM cells [102]