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In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]

In addition,

In animal studies, MOTS-c treatment kept mice on a high-fat, high-calorie regimen leaner and more energetic compared to untreated counterparts

41 Additionally, studies have reported that individuals with Type 2 diabetes mellitus (T2DM) have decreased GSH levels due to compromised GSH synthesis and metabolism enzymes

Possible role of nitric oxide and adrenomedullin in bipolar affective disorder