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We explained that this approach would ensure that the value of the HEBA itself cannot exceed 5 percent of national assignable per capita expenditures expressed as a single value using the ACO's BY3 enrollment proportions, similar to the cap applied to the regional adjustment under 425.656(c)(3) and the cap applied to the prior savings adjustment under 425.658(c)(1)(ii)

Pain was highest during the initial saline flush: Pain at the left tibia was 6.8 +/- 2.9, right tibia 7.9 +/- 2.8, and 4.6 +/- 2.9 for proximal humerus

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In animal models, efficacy is dose-dependent