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Thus, gene therapy with viral vectors protects from neuronal death in animal models of ALS (Lee et al., 2019) and cerebral ischemia (Hayashi et al., 2001), promotes angiogenesis, and reduces apoptosis in SCI (Kitamura et al., 2007)

74 It is unclear, however, whether high doses of ESA are inherently toxic or whether hyporesponsiveness is a marker of adverse outcomes related to co-morbidities

For injury recovery (BPC-157, TB-500), animal studies show promise, but human clinical evidence is essentially nonexistent

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