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There are two hit theories, the first hit for mitochondrial GSH depletion and ROS production and the second hit for JNK activation and translocation into mitochondria, aggravating ROS generation and mitochondrial membrane permeability transition (MPT), leading to hepatocyte death [5]

15 A study of 54 patients diagnosed with SD compared with 54 healthy controls, assessed oxidative stress status and measured serum total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI)

this rarely occurs in the spine) Spinal headache Muscle weakness Increased pain Common side effects from steroids include: Facial flushing Increased appetite Menstrual irregularities Nausea Diarrhea Increased blood sugar, which is usually temporary Some people are not good candidates for spinal injections