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At the tissue level, formation of hyaline membranes and alveolar wall oedema and thickening in addition to microvasculature involvement with pulmonary vessel (intra and extra) hyaline thrombosis, hemorrhage, vessel wall oedema, intravascular neutrophil trapping and immune cell infiltration is appreciated [12,13]

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This stage is generally considered the threshold for a CKD diagnosis, and it falls into two subcategories: 3a and 3b