glutathione and glutamate cysteine liaase Cysteine, Glutathione, Thiol Redox Balance in Astrocytes The complexities of hepatic SLC7A11

It delivers glutathione directly to your cells

Ruvolo PP, Ma H, Ruvolo V, Zhang X, Mu H, Yasuhiro T, Tanaka K, Yoshizawa T, Zhang W, Cortes JE, Andreeff M , Post SM

Rational design of novel immunosuppressive drugs: Analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects

8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

MST1/2 can sense ROS and protect macrophages from oxidative stress by regulating the stability of the transcription factor Nrf2, which is a key transcriptional activator of the antioxidant response in macrophages