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In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)

Now, the difficulty with low B12 levels are that yes, they are more likely to be associated with intestinal problems, but we don't always get overt diarrhea or vomiting with those diseases

Inactive form

This can lead to 1-2 week "out of stock" periods that can be frustrating for researchers who haven't planned ahead

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