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SGLT2 inhibitors are anti-hyperglycemic drugs that have been applied to treat diabetes [223], as well as other metabolic disorders such as CVD and renal dysfunction [224]

doi: 10.1073/pnas.1111415108 2 EnochDAYangHAliyuSHMicallefC

The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier

Rend Lincei Sci Fis E Nat 34:833841

Moreover, several potential target proteins of DZXI related to cell signaling and synaptic chemical transmission, including PDE10A, PRKCG, and GRIA1, were predicted to have a high binding affinity to DZXI main compounds