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Disruption of the classic sleep/wake cycle is commonly caused by staying awake due to work or lifestyle choices (Boivin and Boudreau, 2004, The innate need for sleep is seen throughout evolution (Miyazaki et al., 2017) and its absence can cause a wide range of disturbances throughout the body

May support reductions in fat mass while preserving lean muscle in animal models

While our search was not restricted to a specific time window, we focused on identifying key studies and advancements that have shaped the development of HDTs for TB

However, due to the absence of centrioles, the resultant spindle morphology is reduced in size, and the characteristic astral microtubules at the poles are absent, contributing to the increased instability of spindle assembly in human oocytes

Further research is needed to fully understand the efficacy and which patients might benefit most