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Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future

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dnEFTs exhibited prolonged survival and an immune shift toward an antitumor response in a preclinical model, marked by increased M1 macrophages and reduced M2-associated gene expression

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Additionally, TRF induced changes in signaling pathways regulating energy metabolism, including increased AMPK phosphorylation and decreased Akt kinase phosphorylation