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Collectively, these advancements underscore the potential of ferroptosis as a therapeutic target and highlight the importance of integrating innovative technologies to improve outcomes in GBM treatmentHowever, clinical translation faces hurdles, including GBM heterogeneity, the TME, and lack of reliable biomarkers

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In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression