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For the scavenging activity assay of Mn complex, Mn complexes with RER or Pi were prepared as shown in the Supplementary Table 1

Fasting-refeeding assays Age-synchronized worms were cultured on either experimental or control RNAi plates until Day 1 of adulthood

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Next, we speculated that methionine-based cysteine synthesis pathway may be defective

To ensure viability and adoption in a range of healthcare settings, economic factors, including cost-effectiveness evaluations and fair access to antioxidant therapy, also need to be taken into consideration