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Description

Natural Science Foundation of Jiangxi Province (Nos

This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)

Anti-Inflammatory Properties Chronic inflammation is a common underlying factor in many diseases

and [4] with a follow-up period of 2 months or more after the treatment since this treatment period was stipulated by previous animal studies (11)

Insulin resistance assessed by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was also significantly reduced by week 48 in the Idebenone group but not in the placebo (a paired t-test showed a statistically significant decrease in mean HOMA-IR of 8.52, one-sided p = 0.0160)