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Histamine receptors, agonists, and antagonists in health and disease

Important aspects like fibroblast heterogeneity, functional specialization and cellular plasticity are also discussed as well as the implications that these aspects may have in disease and in the design of novel therapeutics

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Aging can be defined as a progressive and irreversible decline in physiological integrity, driven by the accumulation of stressor-mediated damage and subsequent dysfunction at the cellular, tissue, and organ level [4]

It is important to note that S1P is considered a tumor-promoting lipid due to its impact on autophagy, and increased S1P levels have been identified as a drug-resistance mechanism in some cancer types