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sativa (Fig

The most well-studied role of SFN is its action on the KEAP1-NRF2 pathway

The single study often cited had significant methodological flaws and showed only temporary, modest effects with high rates of adverse events

doi: 10.3390/ijms251810167 47 De JongeCBarrattCLR

Accordingly, the incidence of CIPN approaches nearly 100% for some agents at higher doses (Seretny et al., 2014), although differences in the definition, evaluation and reporting of peripheral neuronal deficits can lead to large variability in the reported occurrence