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4434-A THE ROLE OF BETA-CATENIN IN REGULATING AUTOPHAGY DURING PORPHYRIA Anu Balogun and Kari Nejak-Bowen, University of Pittsburgh Background : The porphyrias are a group of metabolic disorders caused by inherited or acquired deficiency of any of the eight enzymes involved in heme biosynthesis, resulting in abnormal accumulation of heme precursors and their intermediates in organs such as the liver