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Certain conditions may blunt or impede therapeutic response to cyanocobalamin therapy

According to Healthline , vitamin B12 injections are considered generally safe, but some do have allergic reactions or sensitivity

The most successful researchers approach 5-amino-1-MQ as one component of comprehensive metabolic optimization strategies that include proper nutrition, exercise, sleep, and lifestyle factors

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It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)