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Notably, elevated levels of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], a subclass of eicosanoids, activate the intracellular cation channel transient receptor potential vanilloid one and mediate endothelial dysfunction in DM (Otto et al., 2020)

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For most of studies using MIA-induced model, the administration is performed in male mice aged 23 months, followed by analysis of the OA phenotype 12 months later

Recently, the role of the DA receptor in inflammation has been widely studied, mainly focusing on NLRP3 inflammasome, NF-B pathway, and immune cells