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3.3.3 NADPH oxidase Curcumin was found to be a nicotinamide adenine dinucleotide phosphate oxidase (NADPH) oxidase inhibitor responsible for the generation of ROS during inflammation

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Otherwise if such studies consistently provide negative results then a falsification threshold of MAD could be argued, similar to the Tau and amyloid casual theories (Espay et al., 2023)