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Surprisingly, in tissue samples expected to be damaged by OTA, such as kidney, it was found that OTA caused a down-regulation of genes expected to be stimulated by oxidant exposure

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Bronchoconstriction and airway inflammation: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are approximately 1,000-fold more potent than histamine as bronchoconstrictors, making them the major mediators of allergen-induced airway narrowing in asthma