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Research has demonstrated that alterations in intestinal motility and decreased bile acid levels among cirrhosis patients contribute to an overgrowth of intestinal bacteria, resulting in dysbiosis of the gut flora

DOI: 10.1001/jamaneurol.2014.391 49

333 An alternative explanation involves disturbed glycerolipid biosynthesis in GPI deficiency, which could have significant effects on membrane formation, membrane function, and axonal migration

Ahmed MS, Langer H, Abed M, Voelkl J, Lang F

Sortilin also has a cytoplasmic tail that contains sorting motifs that are essential for the binding of adaptor proteins, Golgi-associated -ear-containing ARF-binding proteins (GGAs), and other proteins essential for the trafficking of sortilin [55]