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We noted that the prototypical conformational mutant R175H, which has previously been characterized as responsive to APR-246 [10], was neither significantly enriched nor depleted in the treated population (Supplementary Fig

Hydrogenated ethanonaphthalenes CCHEMISTRY

It is also involved in energy production, via roles in fatty acid and amino acid metabolism

In this Perspective, we first introduce a comprehensive framework for biomarkers applicable in clinical settings and discuss the existing repertoire of biomarkers used in practice