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reported that progressive damage to the intestinal structure during tumor progression in a liver cancer zebrafish model manifested as villus injury, intestinal wall thinning, increased goblet cell numbers, eosinophil infiltration and disrupted intestinal epithelial cell renewal, suggesting that intestinal inflammation may be a promising therapeutic target in cachexia management

Peripherally, KynA has been shown to reduce stress-induced colitis in mice by promoting NLRP3 inflammasome autophagy, demonstrating the pervasive impact of this metabolite [122]

However, the studies included varied widely in terms of design, duration, dosage, and assessment tools, which makes direct comparison challenging

Functional annotation of each secreted protein was performed employing the eggNOG database v5.0 123 using eggNOG-mapper v2 124 , and the results were imported into the Anvio contig database