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Mol Microbiol 105:358372

The normal range is typically 200 pg/ml to 1100 pg/ml

Reduced cobalamin availability leads to: Impaired enterocyte regeneration Villous atrophy and barrier dysfunction Increased intestinal permeability Secondary dysbiosis and chronic inflammation Clinically, this manifests as: Persistent anorexia Weight loss Chronic diarrhea Poor response to standard GI or pancreatitis therapy Low vitamin B12 concentrations have also been associated with increased disease severity and poorer prognosis in dogs with chronic enteropathy and inflammatory bowel disease

Following a successful single oxidationreduction cycle, we probed the ability of compound 1 to undergo repeated redox cycles by exposing the PPIXpeptide to light for 30 min, followed by enzyme incubation for another 30 min (Fig