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furthermore, IGF-1 expression in GH-deficient mice reverses the decreased body size caused by GH deficiency, suggesting that GH exerts its pro-growth function through IGF-1 (Kaplan and Cohen, 2007

Narvin, J., Rojo-Lpez, M.I., Martinez-Santos, P., Rossell, J., Ruiz-Alcaraz, A.J., Alonso, N., Ramos-Molina, B., Mauricio, D., & Julve, J

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Namely, about 73% target genes is silenced, which is comparable with the commercial transfection reagent