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7.6 Integrative perspective and future outlook Taken together, both antioxidant-based and EV-based interventions face shared translational limitations rooted in model relevance, standardization, and clinical validation

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17 ErenY.DirikE.NeelioluS.Erel (2015)

Never exceed the recommended dose, use first time users - start with half the recommended dose to assess tolerance

Notably, NINJ1 knockdown enhances xCT level and activity by increasing xCT stability, resulting in elevated CoA and GSH levels, both of which were required to protect ferroptosis