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This step has 5-hydroxy-L-tryptophan as substrate, pyridoxal 5-phosphate as an optional activator, and is influenced by Al 3+ , Zn 2+ , Ca 2+ , and Mg 2+ levels

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Standard topical glutathione can't penetrate well due to molecular size the exosome vehicle carries it deeper to inhibit tyrosinase and brighten from within

Biomed Pharmacother 179:117298

Figure 2 However, the current understanding of these mechanisms is primarily based on experimental studies and relevant clinical observations, and the relative contribution and clinical significance in humans require further investigation