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1.2.1 The main issue is optimization of drug bioavailability The main issue for any formulation of niclosamide (and indeed other BCS Class II and IV low water-solubility drugs) is how to optimize local bioavailability

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Subsequently, drugs are known to follow the normal pathways for transepithelial transport (Figure 1)

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Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis