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Mutat Res, 171: 169-176

Arjunolic acid attenuates arsenic-induced nephrotoxicity

To create site-specific antibodies for Tyr 249 and 322 of G6PD (Anti-pG6PD (Y249) and Anti-pG6PD (Y322)), synthesized peptides CEPFGTEGRGGY(pi)FDEF and CGEATKGY(pi)LDDPTVP (HuaAn Biotechnology) were coupled to a protein carrier prior to immunization (2 rabbits/antigen)

Secondary endpoints: GSH concentrations in maternal and arterial and venous umbilical cord blood erythrocytes (by stratification based on treatment or degree of IPTB severity) and safety of antenatal NAC supplementation for mothers and infants Considering stratification for IPTB severity, median glutathione concentration in venous cord blood was similar in severe (median: 430 mol/L) and moderate (median: 402 mol/L) IPTB in the NAC arm ( P 1.0), whereas it was lower, however not significantly ( P 0.67), in severe (median: 391 mol/L) than moderate (median: 522 mol/L) IPTB group in the placebo arm (Supplemental Table S3)

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