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Genetic and pharmacological eosinophil depletion led to an enhanced Th1 response, polarization towards M1-like macrophages and resolution of clinical disease, despite an unexpected simultaneous upregulation of IL-4

Alprostadil doesnt cause nausea or systemic effects but can cause dizziness and low blood pressure rarely

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Luo M, Zhang Z, Lu Y, Feng W, Wu H, Fan L

Materials and methods Cell culture and reagents Rat renal proximal tubular cells (RTCs, NRK-52E) were purchased from the Bioresource Collection and Research Center (Hsinchu, Taiwan), and culture cells in Dulbeccos modified Eagles medium (DMEM) were supplemented with an antibiotic/antifungal solution and 5% fetal bovine serum (FBS, pH 7.2)