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Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia

Elevated astrocytic [Cl ] i during sleep sustains a more hyperpolarized E GABA , whereas decreased [Cl ] i in wakefulness restricts Cl availability, thereby shifting E GABA to more positive values

This dual action preserves the negative feedback loop mediated by somatostatin, preventing receptor fatigue

Timing matters tootaking it in the morning or with healthy fats helps maximize its benefits

Side effects of glutathione are not known as it does not lead to any lasting symptoms or cause medical concern due to its naturally occurring properties