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Side Effects : The most common side effects of clonidine and guanfacine include GI upset, headache, mood changes, dry mouth, sexual dysfunction, sedation, changes in blood pressure (most likely hypotension), changes in heart rate (most likely bradycardia), and syncope (17,18)

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In-vitro studies have applied this compound in the context of enzymatic regulation and biochemical signalling, with particular attention to NNMT's reported role in metabolic tissue biology