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Abbreviations PD: Parkinson disease NRF2: Nuclear factor erythroid-2 related factor 2 keap-1: Kelch-like ECH-associated protein 1 NLRP3: NLR family pyrin domain containing protein 3 ROS: Reactive oxygen species HO-1: Heme oxygenase 1 TXNIP: Thioredoxin interacting protein NF-B: Nuclear factor kappa B IL: Interleukin NQO1: NADPH quinone oxidoreductase-1 GPx: Glutathione peroxidase CBP: CREB binding protein IKK: Inhibitory kappa B kinase ARE: Antioxidant response element TRAF6: Tumor necrosis factor receptor associated factor 6 RIP1: Receptor interacting protein P-62/(SQSTM1): Sequestosome 1 CARD: Caspase recruitment domain CK1: Cysteine kinase 2 MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine LPS: Lipopolysaccharide References GBD 2016 Neurology Collaborators