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We used remdesivir as a positive control anti-SARS-CoV-2 agent

Vitamin B12 Deficiency Causes of vitamin B12 deficiency include difficulty absorbing vitamin B12 from food, lack of intrinsic factor (e.g., because of pernicious anemia), surgery in the gastrointestinal tract, prolonged use of certain medications (e.g., metformin or proton pump inhibitors), and dietary deficiency

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Therefore, the existing evidence suggests that the antiviral activity of ivermectin is still experimental, virus-specific, and has pharmacological limitations, and should not be compared to its proven antiparasitic activity in animal clinical practice (59)