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Postmortem examination of patients with purpura fulminans and IMD revealed meningococcal microcolonies associated with the endothelium of different vessels of the two barriers, such as the capillaries of the choroid plexuses, meningeal vessels, and brain parenchyma vessels (Mairey et al., 2006

Acknowledgements We would like to thank the Laboratory of Hematology (GIGA-ULige), the Centre for Protein Engineering (ULige) and the Molecular Imaging and Therapy Laboratory (Vrije Universiteit Brussel) for their excellent technical assistance in our different projects

Khuri SF, Henderson WG, DePalma RG, Mosca C, Healey NA, Kumbhani DJ, et al

Macimorelin as a diagnostic test for adult GH deficiency

Thus, in normal ageing, the decrease in GSH couples with an age-related increase in free Fe 2+ to multiply the likelihood of ferroptosis, leading to death when combined changes in iron and GSH reach a critical threshold ( Figure 7 )