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In the medulla, an elevated UA concentration results in the deposition of urate precipitates and the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome

doi:10.1128/AEM.65.2.523-528.1999

Castillo, P., Bogliolo, M

3.4 As tolerance through improved antioxidant defense system and reduced uptake A surplus of ROS, such as superoxide radicals (O2 + ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH), is produced when toxic substances are present in plants, leading to oxidative stress (124)

Individual animals with PPI-based evidence of NIT were subsequently treated with either NHPN-1010 or saline, wherein intervention was deliberately initiated four weeks (wks) after exposure